abstract：:A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...

journal_title：Marine drugs

authors： Melnikova DI,Magarlamov TY

更新日期：2020-03-23 00:00:00

abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...

journal_title：Marine drugs

authors： Cheng Z,Liu W,Fan R,Han S,Li Y,Cui X,Zhang J,Wu Y,Lv X,Zhang Y,Luo Z,Alias SA,Xu W,Li Q

更新日期：2020-03-16 00:00:00

abstract：:High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...

journal_title：Marine drugs

authors： Yang Y,Du L,Hosokawa M,Miyashita K

更新日期：2020-03-04 00:00:00

abstract：:In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...

journal_title：Marine drugs

authors： Fu B,Lin H,Ramesh Pavase T,Mi N,Sui J

更新日期：2020-02-26 00:00:00

abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...

journal_title：Marine drugs

authors： Pateiro M,Munekata PES,Domínguez R,Wang M,Barba FJ,Bermúdez R,Lorenzo JM

更新日期：2020-02-04 00:00:00

abstract：:Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...

journal_title：Marine drugs

authors： Estupiñán M,Hernández I,Saitua E,Bilbao ME,Mendibil I,Ferrer J,Alonso-Sáez L

更新日期：2020-02-01 00:00:00

abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...

journal_title：Marine drugs

authors： Jøraholmen MW,Bhargava A,Julin K,Johannessen M,Škalko-Basnet N

更新日期：2020-01-31 00:00:00

abstract：:Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...

journal_title：Marine drugs

authors： Gutiérrez M,Santamaría R,Gómez-Reyes JF,Guzmán HM,Ávila-Román J,Motilva V,Talero E

更新日期：2020-01-27 00:00:00

abstract：:The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

journal_title：Marine drugs

authors： Marcellin-Gros R,Piganeau G,Stien D

更新日期：2020-01-25 00:00:00

abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

journal_title：Marine drugs

authors： Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

更新日期：2020-01-17 00:00:00

abstract：:Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...

journal_title：Marine drugs

authors： Pech-Puch D,Pérez-Povedano M,Lenis-Rojas OA,Rodríguez J,Jiménez C

更新日期：2020-01-16 00:00:00

abstract：:We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolab...

journal_title：Marine drugs

authors： Chiu CY,Ling XH,Wang SK,Duh CY

更新日期：2020-01-03 00:00:00

abstract：:Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiency of these metabolites in solvents compatible with cosmetics and their subsequent analysis by HPLC. In the pre...

journal_title：Marine drugs

authors： Chaves-Peña P,de la Coba F,Figueroa FL,Korbee N

更新日期：2019-12-28 00:00:00

abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

journal_title：Marine drugs

authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

更新日期：2019-12-16 00:00:00

abstract：:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...

journal_title：Marine drugs

authors： Zhang F,Braun DR,Rajski SR,DeMaria D,Bugni TS

更新日期：2019-12-12 00:00:00

abstract：:Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...

journal_title：Marine drugs

authors： Yen CH,Young TH,Hsieh MC,Liao LJ,Huang TW

更新日期：2019-11-23 00:00:00

abstract：:Four new xanthene derivatives, penicixanthenes A-D (1-4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher's method, and calcul...

journal_title：Marine drugs

authors： Bai M,Zheng CJ,Nong XH,Zhou XM,Luo YP,Chen GY

更新日期：2019-11-20 00:00:00

abstract：:Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...

journal_title：Marine drugs

authors： Hannan MA,Dash R,Sohag AAM,Moon IS

更新日期：2019-11-13 00:00:00

abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

journal_title：Marine drugs

authors： Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

更新日期：2019-11-06 00:00:00

abstract：:Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...

journal_title：Marine drugs

authors： Henke NA,Wendisch VF

更新日期：2019-10-31 00:00:00

abstract：:Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

journal_title：Marine drugs

authors： Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

更新日期：2019-10-29 00:00:00

abstract：:Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...

journal_title：Marine drugs

authors： Andrud K,Xing H,Gabrielsen B,Bloom L,Mahnir V,Lee S,Green BT,Lindstrom J,Kem W

更新日期：2019-10-29 00:00:00

abstract：:The term metabolic/cardiometabolic/insulin resistance syndrome could generally be defined as the co-occurrence of several risk factors inclusive of systemic arterial hypertension. Not only that organizations, such as the world health organization (WHO) have identified high blood pressure as one of the main risk factor...

journal_title：Marine drugs

authors： Abachi S,Bazinet L,Beaulieu L

更新日期：2019-10-29 00:00:00

abstract：:The hypoxia/reoxygenation (H/R) injury causes serious complications after the blood supply to the kidney is stopped during surgery. The main mechanism of I/R injury is the release of high-mobility group protein B1 (HMGB1) from injured tubular epithelial cells (TEC, TCMK-1 cell), which triggers TLR4 or RAGE signaling, ...

journal_title：Marine drugs

authors： Son M,Oh S,Choi CH,Park KY,Son KH,Byun K

更新日期：2019-10-24 00:00:00

abstract：:Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...

journal_title：Marine drugs

authors： Liu Z,Fan Z,Sun Z,Liu H,Zhang W

更新日期：2019-10-23 00:00:00

abstract：:Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...

journal_title：Marine drugs

authors： Zhang R,Chen J,Mao X,Qi P,Zhang X

更新日期：2019-10-16 00:00:00

abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...

journal_title：Marine drugs

authors： Kim MW,Niidome T,Lee R

更新日期：2019-10-12 00:00:00

abstract：:Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

journal_title：Marine drugs

authors： Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

更新日期：2019-10-11 00:00:00

abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

journal_title：Marine drugs

authors： Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

更新日期：2019-10-11 00:00:00

abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...

journal_title：Marine drugs

authors： Gao J,Du C,Chi Y,Zuo S,Ye H,Wang P

更新日期：2019-10-08 00:00:00

abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...

journal_title：Marine drugs

authors： Nikolaivits E,Agrafiotis A,Termentzi A,Machera K,Le Goff G,Álvarez P,Chavanich S,Benayahu Y,Ouazzani J,Fokialakis N,Topakas E

更新日期：2019-09-30 00:00:00

abstract：:Collagen is widely used in the pharmaceutical, tissue engineering, nutraceutical, and cosmetic industries. In this study, acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were extracted from the skin of red stingray, and its physicochemical and functional properties were investigated. The yields of ASC an...

journal_title：Marine drugs

authors： Chen J,Li J,Li Z,Yi R,Shi S,Wu K,Li Y,Wu S

更新日期：2019-09-28 00:00:00

abstract：:The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...

journal_title：Marine drugs

authors： Oh JH,Ahn BN,Karadeniz F,Kim JA,Lee JI,Seo Y,Kong CS

更新日期：2019-09-21 00:00:00

abstract：:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...

journal_title：Marine drugs

authors： Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A

更新日期：2019-09-17 00:00:00

abstract：:Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...

journal_title：Marine drugs

authors： Jia K,Bian C,Yi Y,Li Y,Jia P,Gui D,Zhang X,Lin W,Sun X,Lv Y,Li J,You X,Shi Q,Yi M,Wu Y

更新日期：2019-08-28 00:00:00

abstract：:Three new benzofuranoids, asperfuranoids A-C (1-3), two new phenylpropanoid derivatives (6 and 7), and nine known analogues (4, 5, and 8-14) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by exten...

journal_title：Marine drugs

authors： Cai R,Jiang H,Zang Z,Li C,She Z

更新日期：2019-08-18 00:00:00

abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...

journal_title：Marine drugs

authors： Esposito G,Mai LH,Longeon A,Mangoni A,Durieu E,Meijer L,Van Soest R,Costantino V,Bourguet-Kondracki ML

更新日期：2019-08-15 00:00:00

abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...

journal_title：Marine drugs

authors： Citkowska A,Szekalska M,Winnicka K

更新日期：2019-08-05 00:00:00

abstract：:Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...

journal_title：Marine drugs

authors： Schmitz C,Auza LG,Koberidze D,Rasche S,Fischer R,Bortesi L

更新日期：2019-08-01 00:00:00

abstract：:Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

journal_title：Marine drugs

authors： Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

更新日期：2019-07-28 00:00:00